Alvin Kamara is easily the safest out of the top three running backs, and he still has equally as high upside. He is in the best offense out of the three and has put up a ton of points in both of his first two years in the league. Mark Ingram is now gone, but Latavius Murray will now fill his role as a power running back. The difference between Ingram and Murray is that Ingram is a much better pass-catcher, so even though Murray will take over Ingram's role in the run game, Kamara will likely take a lot of Ingram's targets. This gives him the upside of 100+ catches. On top of that, Kamara should actually see positive regression next year. In his rookie season, Kamara averaged 6.1 yards per carry and 10.2 yards per reception. Last year, however, Kamara only averaged 4.6 yards per carry and 8.8 yards per reception. Expect his efficiency to fall somewhere in between next year. That, combined with Kamara's workload from last year (and possible increased workload with Ingram gone), gives him a great chance to have over 2,000 yards from scrimmage. Kamara had an outstanding 18 touchdowns last year, and he will have the chance to repeat that performance or possibly even build upon it next year, as he had the second-most red-zone touches for a running back last year behind only Todd Gurley. Now that Gurley's workload is going to decrease, Kamara should lead the league in red-zone touches. The main issue with Kamara is that he isn't a true workhorse. He won't be getting over 350 touches, but due to his insane efficiency and the fact that the Saints use him perfectly, he still has the ability to finish as the top running back in fantasy. There is a chance, however, that Latavius Murray doesn't work well in the Saints offense. This happened with Adrian Peterson during Kamara's rookie year, and if it happens to Murray, Kamara could see 350+ touches, giving him the upside to have the best fantasy season ever for a running back. When Kamara was a workhorse during the first four games of last year, Kamara averaged an insane 33 PPR points per game. If Murray doesn't work out Kamara could post those types of numbers for an entire season. This is very unlikely to happen, but the possibility gives Kamara slightly higher upside. Kamara has a floor of 1,600 total yards, 12 touchdowns, and 80 catches if he plays a full season. He has a ceiling for 2,000+ total yards, 20+ touchdowns, and 100+ catches, which are record-breaking numbers for a running back. Overall, Kamara is the safest player in fantasy and still has the upside to finish as the top running back in fantasy, making him the obvious choice with the first pick.